In 1994, a comic adaptation was published by Alexandre Jubran. HarperOne, a HarperCollins imprint, produced an illustrated version of the novel, with paintings by the French artist Mœbius, but failed to convince Coelho "to consent to the full graphic-novel treatment." The Alchemist: A Graphic Novel was published in 2010, adapted by Derek Ruiz and with artwork by Daniel Sampere.
In 2002, a theatrical adaptation of The Alchemist was produced and performed in London. Since then there have been several productions by the Cornish Collective. In 2009 an Indian adaptation of the novel was staged by Ashvin Gidwani Productions.
In music, The Alchemist has inspired numerous bands of the same name. In 1997 RCA Red Seal released The Alchemist's Symphony by composer and conductor Walter Taieb with the support of Paulo Coelho, who wrote an original text for the CD booklet. In September 2009, an orchestral performance was conducted at the Ansche Chesed Synagogue in New York. Inspired by The Alchemist, "an orchestral performance" was composed by One World Symphony for composer and conductor Sung Jin Hong's wedding.