Most prokaryotes have most of their DNA packaged in a circular chromosome. The DNA of eukaryotes are packaged as chromatin, tightly coiled DNA strands wound around proteins called histones.
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Because eukaryotic cells typically carry much more DNA than prokaryotic cells, eukaryotic DNA must be bound to proteins and tightly coiled. Packaged in this way, eukaryotic DNA is able to be contained within the tight confines of a cell. This packaging also allows the DNA of eukaryotic cells to be replicated more easily. The DNA of prokaryotes, which is much less than in eukaryotic cells, can be isolated in small circular pieces of DNA.