1) The chondrocytes in the center of hyaline cartilage will enlarge & form struts which will begin to calcify. Then the enlarged chondrocytes will die and leave cavities in the cartilage. 2) The blood vessels will grow around the edges of cartilage. Cells in the perichondrium will change to osteoblasts, while producing a layer of superficial bone around the shaft which will continue to grow and become compact bone. 3) Blood vessels enter the cartilage, bringing in osteoblasts, and spongy bone develops at the primary ossification center. 4) Remodeling creates a marrow cavity and bone replaces cartilage at the metaphyses. 5) Capillaries and osteoblasts will enter the epiphyses, creating secondary ossification centers. 6) Epiphyses will fill with spongy bone and the cartilage remaining within the joint cavity is the articulation cartilage (hyaline cartilage only in this phase).
Work Step by Step
This process, endochondral ossification, is essential in forming bones.