The film Tender Is the Night (1962), based on the novel, starred Jason Robards and Jennifer Jones as the Divers. The song "Tender Is the Night" from the movie soundtrack was nominated for the 1962 Academy Awards for Best Song.
A television mini-series of the book, with script by Dennis Potter, music by Richard Rodney Bennett, and with Mary Steenburgen and Peter Strauss as Nicole and Dick, was made by the BBC and shown in 1985 by the BBC in the United Kingdom, the Canadian Broadcasting Corporation in Canada, and Showtime in the United States.
A stage adaptation by Simon Levy, with permission of the Fitzgerald Estate, was produced at The Fountain Theatre, Los Angeles in 1995. It won the PEN Literary Award in Drama and several other awards.
Boris Eifman's 2015 ballet Up and Down is based loosely on the novel.