Pygmalion remains Shaw's most popular play. The play's widest audiences know it as the inspiration for the highly romanticized 1956 musical and 1964 film My Fair Lady.

Pygmalion has transcended cultural and language barriers since its first production. The British Museum contains "images of the Polish production...; a series of shots of a wonderfully Gallicised Higgins and Eliza in the first French production in Paris in 1923; a fascinating set for a Russian production of the 1930s. There was no country which didn't have its own 'take' on the subjects of class division and social mobility, and it's as enjoyable to view these subtle differences in settings and costumes as it is to imagine translators wracking their brains for their own equivalent of 'Not bloody likely'."[20]

Joseph Weizenbaum named his chatterbot computer program ELIZA after the character Eliza Doolittle.[21]

Peter Hogg's novel Smilla's Sense of Snow features a "Professor Higgins" character - i.e., a skilled linguist able to deduce a person's geographical and social circumstances from hearing them speak; in that case, Hogg's linguist is an expert on the Inuit languages and dialects of Greenland, but is equally at home in identifying at a glance the various dialects and sociolects of Danish.

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