Rukmani and Nathan love each other and their marriage begins in relative peace and plenty. When a large tannery is built in the neighboring village, it begins insidiously destroying their lives. As the tannery grows larger and more prosperous, Rukmani and Nathan struggle to feed their children and to pay the rent on the land that gives them life. Although matters continue to worsen, they quietly resign themselves to ever-increasing hardships—flood, famine, even death—and cling to their hopes for a better future.
Dr. Kennington, or "Kenny", an itinerant English doctor, is an important presence in the novel. Although Rukmani's fatalistic attitude toward hardship exasperates him, he feels compassion for her and helps her when he can. At the end, Rukmani goes to live with her youngest son, now a doctor at the hospital Kenny has built.
Throughout the novel, Rukmani is faced with struggle after struggle with no indication that her circumstances will improve. Each time her situation worsens, she endures quietly, holding on to the hope that things will soon be better.