1933 film
In 1933, the novella was very loosely adapted as a movie, Advice to the Lovelorn, starring Lee Tracy, produced by Twentieth Century Pictures—before its merger with Fox Film Corporation—and released by United Artists. Greatly changed from the novel, it became a comedy/drama about a hard-boiled reporter who becomes popular when he adopts a female pseudonym and dispenses fatuous advice. He agrees (for a hefty payment) to use the column to recommend a line of medicines, but finds out they are actually harmful drugs when his mother dies. He then agrees to help the police track down the criminals. The movie ends with the main character happily married.
1957 Broadway play
In 1957, the novella was adapted into a stage play entitled Miss Lonelyhearts by Howard Teichmann. It opened on Broadway at the Music Box Theatre on October 3, 1957, in a production directed by Alan Schneider and designed by Jo Mielziner and Patricia Zipprodt. It starred Pat O'Brien. It ran for only twelve performances.
1958 film
In 1958 the plot was again filmed as Lonelyhearts, starring Montgomery Clift, Robert Ryan, and Myrna Loy, produced by Dore Schary and released by United Artists. Although following the plot of the book more closely than Advice to the Lovelorn, many changes were made. The movie greatly softens the cynical edge of the original book, and the story is once more given a happy ending—the woman's husband is talked out of shooting Miss Lonelyhearts, who finds happiness with his true love, and Shrike is considerably kinder at film's end.
1983 film
The novella was adapted by Robert E. Bailey and Michael Dinner into a 1983 TV movie, Miss Lonelyhearts, starring Eric Roberts in the lead role. Eric Roberts would coincidentally play the lead role in the unrelated 1991 film Lonely Hearts.
2006 opera
In 2006, composer Lowell Liebermann completed Miss Lonelyhearts, a two-act opera. The libretto was written by J. D. McClatchy. The opera, which received its premiere in 2006 at the Juilliard Opera Center, was commissioned by the Juilliard School for its centennial celebration.
The opera was co-produced by the Thornton School of Music Opera Program at University of Southern California, and received its West Coast premiere at the school in 2007. Both premieres were directed by Thornton faculty member Ken Cazan.