- Tom Cruise as Chief John Anderton, Precrime program commanding officer.
- Max von Sydow as Lamar Burgess, Director of Precrime.
- Colin Farrell as Danny Witwer, agent from Department of Justice.
- Samantha Morton as Agatha Lively, described as the most "talented" of the three precogs.
- Neal McDonough as Gordon "Fletch" Fletcher, a Precrime officer.
- Patrick Kilpatrick as Geoffrey Knott, a Precrime officer.
- Michael and Matthew Dickman as Arthur and Dashiell "Dash" Arkadin, the precog twins.
- Lois Smith as Dr. Iris Hineman, creator of precrime.
- Kathryn Morris as Lara Anderton, estranged wife of Anderton.
- Mike Binder as Leo Crow, the Precrime victim who is supposed to be killed by Anderton.
- Steve Harris as Jad Watson, agent who assists Anderton in temple.
- Jessica Harper as Anne Lively, Agatha's mother.
- Tim Blake Nelson as Gideon, a guard of the Precrime prison.
- Daniel London as Norbert "Wally" Wallace, the caretaker of the Precogs.
- Peter Stormare as Dr. Solomon P. Eddie, an underground surgeon Anderton previously arrested who replaces his eyes.
The cast also features Jessica Capshaw as Evanna, Precrime's transport pilot, Tyler Patrick Jones as Sean Anderton, John and Lara's son supposedly murdered by Crow, Jason Antoon as Rufus T. Riley, cyber parlor proprietor; Nancy Linehan Charles as Celeste Burgess, Lamar's wife; Victor Raider-Wexler as Attorney General Arthur Nash, Arye Gross as Howard Marks, Ashley Crow as Sarah Marks, David Stifel as Lycon, Anna Maria Horsford as Casey, Joel Gretsch as Donald Dubin, Tom Choi as Nick Paymen, Caroline Lagerfelt as Greta van Eyck and William Mapother (Tom Cruise's cousin) as a hotel clerk, Frank Grillo as Precrime Cop, Jim Rash as Technician.
Cameron Diaz, Cameron Crowe, and Paul Thomas Anderson make uncredited cameo appearances as subway passengers.
