- Donald Sutherland as Capt. Benjamin Franklin "Hawkeye" Pierce Jr.
- Elliott Gould as Capt. John Francis "Trapper John" McIntyre
- Tom Skerritt as Capt. Augustus "Duke" Forrest
- Sally Kellerman as Major Margaret "Hot Lips" Houlihan
- Robert Duvall as Major Frank Burns
- Roger Bowen as Lt. Col. Henry Braymore Blake
- René Auberjonois as Father John Patrick Francis "Dago Red" Mulcahy
- David Arkin as Sergeant First Class Wade Douglas Vollmer (incorrectly identified as "Staff Sergeant" in the credits.)
- Jo Ann Pflug as Lt. Maria "Dish" Schneider
- John Schuck as Capt. Walter "The Painless Pole" Waldowski, DDS
- Carl Gottlieb as Capt. John "Ugly John" Black
- Danny Goldman as Capt. Dennis Murrhardt
- Corey Fischer as Capt. Patrick "Band-Aid" Bandini
- Indus Arthur as Lt. Leslie
- Dawne Damon as Lt. Wilma "Scorch" Storch
- Tamara Horrocks as Capt. Bridget "Knocko" McCarthy
- Gary Burghoff as Cpl. Walter "Radar" O'Reilly
- Ken Prymus as Pfc. Seidman
- Fred Williamson as Capt. Oliver Harmon "Spearchucker" Jones
- Michael Murphy as Capt. Ezekiel Bradbury "Me Lay" Marston V
- Timothy Brown as Cpl. Judson
- Bud Cort as Pvt. Lorenzo Boone
- G. Wood as Brig. Gen. Charlie Hammond
- Kim Atwood as Ho-Jon
- Dale Ishimoto as Korean doctor
- Bobby Troup as Sgt. Gorman
- Marvin Miller as PA announcer
- Ben Davidson as Football opponent #88
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