- Chris Cooper as Sam Deeds
- Elizabeth Peña as Pilar
- Kris Kristofferson as Charlie Wade
- Matthew McConaughey as Buddy Deeds
- Míriam Colón as Mercedes Cruz
- Clifton James as Hollis Pogue
- Jeff Monahan as young Hollis Pogue
- Ron Canada as Otis Payne
- Gabriel Casseus as young Otis Payne
- Joe Morton as Delmore Payne
- Carmen de Lavallade as Carolyn Payne
- Eddie Robinson as Chet Payne
- LaTanya Richardson as Sgt. Priscilla Worth
- Tony Plana as Ray
- Frances McDormand as Bunny
- Jesse Borrego as Danny Padilla
- Stephen Mendillo as Sgt. Cliff
- Oni Faida Lampley as Celie Payne
- Eleese Lester as Molly
- Tony Frank as Fenton
- Gordon Tootoosis as Wesley Birdsong
- Beatrice Winde as Minnie Bledsoe
- Chandra Wilson as Athena Johnson
- Richard Reyes as Jorge[6]
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