• Victor Frankenstein – Protagonist and narrator of most of the story. Creates the monster.
  • The Creature (Frankenstein's monster) – The creature created by Victor Frankenstein.
  • Captain Robert Walton – Captain of the boat which picked up Victor. On his journey to sail to the North Pole, he writes numerous letters detailing the expedition and his subsequent encounters with Victor and the Creature to Mrs. Margaret Saville.
  • Margaret Saville – Resident of England. Sister of Robert Walton. Addressee of letters written by him.
  • Beaufort – A merchant. Caroline Beaufort's father. One of the most intimate friends of Victor's father.
  • Caroline Beaufort – Beaufort's daughter, Victor's mother.
  • Alphonse Frankenstein – Victor's father, from a wealthy family and respected by all who know him.
  • Elizabeth Lavenza – Victor's fiancée and adopted sister, sometimes referred to as his cousin.
  • Ernest Frankenstein – Victor's brother. Seven years younger than Victor. He is left alone by the Creature, and ultimately becomes the only surviving member of his family as of the story's close.
  • William Frankenstein – Victor's youngest brother.
  • Henry Clerval – Victor's best friend, both in childhood and adulthood. The son of a merchant of Geneva.
  • Justine Moritz – Daughter of Madame Moritz. Moved in with the Frankenstein family at age of 12, and hanged for the murder of William.
  • M. Krempe – A professor of natural philosophy at the University of Ingolstadt. An uncouth man, but deeply imbued in the secrets of his science. Influenced Victor.
  • M. Waldman – A professor, at Ingolstadt. Influenced Victor and restored his interest in science.
  • De Lacey – A blind old man descended from a "good family" in France. His family was observed by the monster, and unbeknownst to them, taught him to speak and read.
  • Agatha De Lacey – Daughter of De Lacey. Described as very kind and gentle.
  • Felix De Lacey – Son of De Lacey. His family lost its fortune and was exiled after he helped a Turkish merchant who had been wrongly convicted of a crime.
  • Safie – Daughter of the Turkish merchant and a Christian Arab. Felix's girlfriend.
  • Mr. Kirwin – A magistrate who presides over Victor's murder charge.
  • Daniel Nugent – A witness against Victor in his murder charge.

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