The book was adapted into a film by director Wes Anderson. It was released in 2009 and features the voices of George Clooney as Mr. Fox, Meryl Streep as Mrs. Fox, Bill Murray as Badger, Robert Hurlstone as Boggis, Hugo Guinness as Bunce and Michael Gambon as Bean. The movie's plot focuses more on Mr. Fox's relationship to Mrs. Fox and his son, which is pitted against Mr. Fox's desire to steal chickens as a means of feeling like his natural self. The movie adds scenes before Mr. Fox attacks the three farmers and after their bulldozing of the hill, as well as a slightly altered ending and more background on Mr. Fox's past life as a thief of food. The Foxes' four children are replaced by Ash, a small and insecure fox who seeks his father's approval and Mr. Fox's nephew Kristofferson, who excels in athletics and is a source of jealousy for Ash.
The book was adapted into a play of the same name by David Wood and was first performed at the Belgrade Theatre in Coventry in 2001. The play is licensed (in the U.K. only) through Casarotto Ramsay Ltd. for repertory performances and Samuel French Ltd. for amateur performances.
A musical adaptation of the book ran at the Nuffield Theatre in Southampton during Christmas 2016 before touring the U.K. in early 2017.
Tobias Picker adapted the book into an opera (the only adaptation with origins in the U.S.) which had its world premiere at the Los Angeles Opera performing 9–22 December in 1998. the Opera starred Gerald Finley as Mr Fox and Suzanna Guzman as Mrs Fox. A specially commissioned new version of this opera by Opera Holland Park was performed in the gardens and natural scenery of Holland Park in the summer of 2010 staged by Stephen Barlow. This version starred Grant Doyle as Mr. Fox, Olivia Ray as Mrs. Fox, Henry Grant Kerswell, Peter Kent and John Lofthouse as Farmers Boggis, Bunce and Bean.