Coraline inspired the "Coralisa" segment of The Simpsons episode "Treehouse of Horror XXVIII", which aired on 22 October 2017. Neil Gaiman provided the voice of the Simpsons' cat, Snowball V.
With the help of the animation studio Laika, director Henry Selick released a stop motion film adaptation in 2009 that received critical acclaim. At the 82nd Academy Awards, the film was nominated for Best Animated Feature but lost to Pixar's Up. In the film, Coraline is depicted as having short blue hair and freckles. Henry Selick added a new character, Wyborn "Wybie" Lovat, who is an annoyance at first to Coraline in the real world but she grows to like him. In the Other World he cannot speak, but is an ally to Coraline. At the end of the film, Coraline reaches out to help Wybie tell his grandmother what is behind the little door.
A comic book adaptation, published in 2008, was illustrated by P. Craig Russell and lettered by Todd Klein.
A theatrical adaptation, with music and lyrics by Stephin Merritt and book by David Greenspan, premiered on 6 May 2009, produced by MCC Theater and True Love Productions Off-Broadway at The Lucille Lortel Theatre. Nine-year-old Coraline was played by an adult, Jayne Houdyshell, and the Other Mother was played by David Greenspan.
A video game adaptation, based on the film, was published and developed by D3 Publisher of America. The game was released on 27 January 2009 for the PlayStation 2, Nintendo DS and Wii platforms and contains features such as playing as Coraline, interacting with other characters, and playing minigames. The game received mostly negative reviews.
An opera by Mark-Anthony Turnage, based on the novella, made its world premiere at the Barbican Centre in London on 27 March 2018.