Kamble was the National President and one of the founding members of Dalit Panther. He was also the National General Secretary of Janata Dal, a member of the National Election Committee – Janata Dal (Parliamentary Board), and in charge of Election Committee of Bihar State. He successfully led the Namantar Andolan of Marathwada University as a president of Dalit Panther of India.
When the dispute arose on the book 'Riddles in Hinduism' (Appendix, Riddles of Ram & Krishna) authored by Dr.Ambedkar, Kamble led an intellectual fight and a march with Ten Lakh people (January 1987) and the provision for reservation to Buddhist, Backward class, and minorities with Prime Minister Vishwanath Pratap Singh. He got promises and assurance to implement the Mandal Commission;Second Backward class Commission, with an immediate effect (1989).
Kamble resigned from Janata Dal on the issue of Dalit president of India. He led a march as a President of Dalit Panther during an Assembly Session at Nagpur on the issue of publishing Dr. Ambedkar's complete body of literature (1979). He later worked as a member of Dr. B.R. Ambedkar Charitra Sadhane Publication which was borne by a march.
Kamble worked as an editor for the book Dr. B.R. Ambedkar Writings & Speeches. Maharashtra Government declared a decision to omit a part from the Appendix (Riddles in Hinduism, 'Dr. B.R. Ambedkar Writings and Speeches' Volume 4). For this issue he left the editor's committee and filed a lawsuit in the High Court against the Maharashtra Government.
He inaugurated 'Manusmruti Cremation Conference' at Karur by Dravida Kazhagam, founded by Periyar E. V. Ramasamy (1983). He also inaugurated and led a march to protest against the outrageous behavior on Dalit community at Karamchedu (1987). He led Samajik Nyay Jyoti (Social Justice Flame) with Ram Vilas Paswan from Chundur to New Delhi (1992). He was the Chief Guest at 'All India Dalit Writer's Conference' (October 1987) and worked as a convener of the 'All India Dalit Writer's Association. He inaugurated a Social Gathering of Dalit Literature at Bangalore (1986) and gave a speech at the conference of the Namantar-Mandal (1984). He inaugurated the 9th Marathi Conference at Badoda (1995) and gave a speech at the All India Dalit Liberation conference (6 December 1987). He undertook an editorial work for the periodicals Ambedkar Bharat, Shoonya, and Sangharsh.
Kamble worked as a member of National Police Commission and as a committee member for the advisory board of Special Department for Scheduled Caste & Scheduled Tribes at the University of Mumbai. He was a president of 3rd All India Conference on Dr. Ambedkar's Literature at Wardha and also a president at the World Conference on Buddha, Phule, and Ambedkar Literature at Kalyan ( 23–25 March 2002).