Killigrew died of smallpox in 1685, when she was only 25 years old. She was buried in the chancel of the Savoy Chapel (dedicated to St John the Baptist) on 15 June 1685.[2]: 11 A monument was built in her honour[16][9] but later destroyed by a fire.[29] Her mother, Judith Killigrew, was also buried there, as of 2 February 1683.[2]: 11
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