In 1966, James Ferman directed Amerika for the BBC series Theatre 625.
Zbyněk Brynych directed the 1969 film Amerika oder der Verschollene for the German TV station ZDF.
The novel was adapted for the screen as the film Klassenverhältnisse (Class Relations) by Jean-Marie Straub and Danièle Huillet in 1984.
Federico Fellini’s Intervista revolves around the fictional filming of this novel’s adaptation.
Danish director Lars von Trier's 1991 art drama film Europa was heavily influenced by the novel, so much so that its title is meant to "mirror" the one of the novel.
The novel was made into a movie called Amerika in 1994 by Czech director Vladimír Michálek.
In 2004, a version adapted for the stage by Ip Wischin and directed by Tino Geirun, toured the USA.
German artist Martin Kippenberger attempted to conclude the story in his installation The Happy Ending of Franz Kafka's "Amerika".
In 2012, the Tête à Tête opera company performed Samuel Bordoli's adaptation, the chamber opera Amerika.
Canadian cartoonist Réal Godbout released a graphic novel adaptation in French, as L’Amérique, ou Le Disparu, published by Les Éditions La Pastèque in 2013. In 2014 it appeared in English, as Amerika (translated by Helge Dascher), published by Conundrum Press (Canada).  
In 2016, American rock band Young the Giant released their single Amerika as part of an inspiration from Kafka's Amerika.