- In 1945, the syndicated radio programme The Weird Circle adapted the novel into a condensed 30-minute drama.
- The 1979 Mexican film El Año de la Peste (The Year of the Plague), directed by Mexican director Felipe Cazals from a screenplay written by Gabriel García Márquez, was based on A Journal of the Plague Year.
- The Oscar-nominated 1999 German stop motion animated short film Periwig Maker is based on A Journal of the Plague Year.[7]
- A 2016 BBC Radio 4 play adapted the novel into a 60-minute drama.[8]
A Journal of the Plague Year also served as the initial inspiration for Anthony Clarvoe's play The Living.