The title is from the Natalie Merchant song of the same name and lyrics from the song are printed as an epigraph just before part one of the novel.

"Doctors have come from distant cities just to see me stand over my bed disbelieving what they're seeing. They say I must be one of the wonders of god's own creation and as far as they can see they can offer no explanation" [14]

The title is also referenced in the novel when Auggie states, "I'm actually considered something of a medical wonder, you know" [15]

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