The book has inspired a number of adaptations:
Silent film versions
- 1911: Vanity Fair: directed by Charles Kent.
- 1915: Vanity Fair: directed by Charles Brabin.
- 1922: Vanity Fair: directed by W. Courtney Rowden.
- 1923: Vanity Fair: directed by Hugo Ballin
Sound film versions
- 1932: Vanity Fair: directed by Chester M. Franklin and starring Myrna Loy
- 1935: Becky Sharp: starring Miriam Hopkins and Frances Dee, the first feature film shot in full-spectrum Technicolor
- 1976 Vanity Fair: directed by Igor Ilyinsky & Mariette Myatt. In 2 episodes. (USSR).
- 2004: Vanity Fair: directed by Mira Nair. Starring Reese Witherspoon as Becky Sharp and Natasha Little from the television miniseries of 'Vanity Fair' as Lady Jane Sheepshanks. This work rewrites Becky as a sympathetic character, whose faults are "understandable."
- 1967: Vanity Fair: BBC miniseries adapted by Rex Tucker starring Susan Hampshire as Becky Sharp, for which she received an Emmy Award in 1973. This version was also broadcast in 1972 in the US on PBS television as part of Masterpiece Theatre.
- 1987: Vanity Fair: BBC miniseries starring Eve Matheson as Becky Sharp, Rebecca Saire as Amelia Sedley, James Saxon as Jos Sedley and Simon Dormandy as Dobbin
- 1998: Vanity Fair: BBC miniseries starring Natasha Little as Becky Sharp
- The CBS Radio series Campbell Playhouse, hosted by Orson Welles, broadcast a one-hour adaptation on 7 January 1940 featuring Helen Hayes and Agnes Moorehead.
- The NBC Radio series Favorite Story, hosted by Ronald Colman, broadcast a half-hour adaptation with Joan Lorring as "Becky Sharp".
- BBC Radio broadcast an adaptation of the novel by Stephen Wyatt in 2004 starring Emma Fielding as Becky, Stephen Fry as the Narrator, Katy Cavanagh as Amelia, David Calder, Philip Fox, Jon Glover, Geoffrey Whitehead as Mr. Osborne, Ian Masters as Mr. Sedley, Alice Hart as Maria Osborne and Margaret Tyzack as Miss Crawley. This was subsequently re-broadcast on BBC Radio 7 in 20 fifteen-minute episodes.