- Ewan McGregor as Mark "Rent Boy" Renton
- Ewen Bremner as Daniel "Spud" Murphy
- Jonny Lee Miller as Simon "Sick Boy" Williamson
- Robert Carlyle as Francis "Franco" Begbie
- Kevin McKidd as Thomas "Tommy" Mackenzie
- Kelly Macdonald as Diane Coulston
- Peter Mullan as Swanney "Mother Superior"
- Fiona Bell as Diane's Mother
- Vincent Friell as Diane's Father
- Pauline Lynch as Lizzy
- Susan Vidler as Allison
- Eileen Nicholas as Mrs Renton
- James Cosmo as Davie Renton
- Shirley Henderson as Gail Houston
- Stuart McQuarrie as Gav Temperley/American Tourist
- Irvine Welsh as Mikey Forrester
- Kevin Allen as Andreas
- Keith Allen as Hugo the Dealer, reprising his role from Shallow Grave (1994)
- Dale Winton as Game Show Host
- Lauren and Devon Lamb as Baby Dawn (uncredited)[11]
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