Zola adapted the novel into a play, first staged in 1873. It was not performed in London until 1891, under the auspices of the Independent Theatre Society, since the Lord Chamberlain's Office refused to license it.
Recent stage productions include:
- 2006 for the Royal National Theatre, London, adaptation written by Nicholas Wright.
- 2007 production of the Nicholas Wright adaptation by Quantum Theatre in Pittsburgh, PA. Staged in the empty swimming pool of the Carnegie Library in Braddock, PA.
- 2008 production at Riverside Studios, London, adaptation by Pauline McLynn.
- 2009 production at Edinburgh Fringe Festival performed by pupils of The Cheltenham Ladies' College (adapted by Fiona Ross)
- 2014 production touring from Bath, adapted by Helen Edmundson
The novel was made into several films, including:
- A 1915 silent film adaptation, which was made in Italy. It was directed by Nino Martoglio.
- A 1928 German silent film
- A 1950 BBC adaptation starring Sonia Dresdel as Thérèse.
- A 1953 French adaptation with Simone Signoret.
- A 1956 German made-for-TV movie adaptation.
- A 1965 Swedish made-for-TV movie adaptation.
- A 1966 German made-for-TV movie adaptation.
- A 1977 Mexican TV series adaptation.
- A 1979 Belgian made-for-TV movie adaptation.
- A 1980 BBC serial adaptation starring Kate Nelligan as Thérèse and Alan Rickman.
- A 1985 Italian mini-series adaptation.
- A 1998 BBC Radio 4 radio adaptation starring Anna Massey as Thérèse.
- A 2009 BBC Radio 4 A "Classic Serial" adaptation in two parts starring Charlotte Riley as Thérèse and Andrew Buchan as Laurent.
- The 2009 Korean horror film Thirst borrowed a number of plot elements from Thérèse Raquin.
- The 2013 English-language adaptation, In Secret, starring Elizabeth Olsen as Therese, Jessica Lange as Madame Raquin, Oscar Isaac as Laurent and Tom Felton as Camille. Directed by Charlie Stratton.
- The 2014 UK stage adaptation of 'Thérèse Raquin', with music by Craig Adams and Book and Lyrics by Nona Shepphard, featuring Julie Atherton as Thérèse, Tara Hugo as Madame, Jeremy Legat as Camille and Ben Lewis/Greg Barnett as Laurent. After a sold out run at The Finborough Theatre the Theatre Bench production transferred to Park Theatre in Finsbury Park and was nominated for a West End Frame award. A cast recording is planned for release in 2015.
An opera based on the novel has been written by the composer Michael Finnissy. Another opera Thérèse Raquin by Tobias Picker opened in 2000.
The novel was also made into a Broadway musical entitled Thou Shalt Not, with music composition by Harry Connick, Jr..
The novel (rewritten in the style of James M. Cain) was the basis of the play "The Artificial Jungle" by Charles Ludlam.
Neal Bell adapted the novel into a play under the same title. The following represents a short production history of Bell's play. It was first produced at New York University by Playwrights Horizons Theatre School on December 3, 1991, directed by Edward Elefterion, with Katie Bainbridge as the title role. Its first professional production was at the Williamstown Theatre Festival on June 30, 1993, directed by Michael Greif, with Lynn Hawley as Thérèse. On July 10, 1994, Michael Greif, in conjunction with La Jolla Playhouse in California, put up the West Coast premiere with Paul Giamatti in the role of Camille. Its professional New York premiere was on October 27, 1997, at the Classic Stage Company, directed by David Esbjornson, with Elizabeth Marvel as Thérèse Raquin. The Los Angeles premiere was directed by Charlie Stratton, with Leslie Hope as Thérèse