In the Sunday comic strip Calvin and Hobbes, Calvin's teacher Miss Wormwood, who repeatedly fails to teach Calvin the value of education and attentiveness, is named after Screwtape's protégé.
Affectionately Yours, Screwtape: The Devil and C.S. Lewis (January 1, 2007), directed by Tom Dallis and written by Amy Dallis, aired on the History Channel
In 2010, the Marine Corps Gazette began publishing a series of articles entitled "The Attritionist Letters" styled in the manner of The Screwtape Letters. In the letters, General Screwtape chastises Captain Wormwood for his inexperience and naivete while denouncing the concepts of maneuver warfare in favor of attrition warfare.
Called To Arms' concept album Peril and the Patient (August 10, 2010) is based entirely on The Screwtape Letters.
In U2's music video for the song "Hold Me, Thrill Me, Kiss Me, Kill Me" (1995), an animated Bono is seen walking down the street holding the book The Screwtape Letters. While on stage during the Zoo TV Tour Bono would dress as Mr. MacPhisto, his alter ego. Bono would wear a gold suit and devil horns and usually make prank calls to politicians.
The lyrics for The Receiving End of Sirens' song "Oubliette (Disappear)", from the album The Earth Sings Mi Fa Mi (2007) were inspired by a passage from The Screwtape Letters.
U.S. President Ronald Reagan quoted The Screwtape Letters in his famous 1983 speech to the National Association of Evangelicals.