Writing in The New York Times, Michiko Kakutani called the book "powerful", but said the social allegories were at times "heavy-handed".[2]
John Mullan, reviewing the book in British newspaper The Guardian, said the book was "remarkable not just for its story, but also for its narrative form".[3]
The Poisonwood Bible was selected for Oprah's Book Club in 1999. Additionally that year, the book was a finalist for the Pulitzer Prize in fiction.[4] It won the 2000 Boeke Prize.
In March 2016, the book was discussed on BBC Radio 4's A Good Read.[5]