Kino: The young Indian pearl diver who finds the magnificent pearl and whose life is partially destroyed by this pearl.
Juana: Kino's wife and faithful partner in eking out a meager living; she is obedient and devoted to her family.
Coyotito: Coyotito is Kino and Juana's infant son; he is bitten by a scorpion and recovers miraculously only to be later killed by a bullet, a bullet intended for Kino.
Juan Tomás: Kino's brother, advisor, and his only protector when Kino is hunted for murder.
Apolonia: Juan's fat wife, who has no real significance in the story.
The Doctor: A thoroughly heartless, self-seeking man whose love of money is displayed when he refuses to help Coyotito because Kino cannot pay him his fee.