- A film adaptation, eponymously titled The Name of the Rose (1986), was directed by Jean-Jacques Annaud, and starred Sean Connery as William of Baskerville and Christian Slater as Adso.
- A play adaptation by Grigore Gonţa had premiered at National Theatre Bucharest in 1998, starring Radu Beligan, Gheorghe Dinică, and Ion Cojar.
- A two-part radio drama based on the novel and adapted by Chris Dolan was broadcast on BBC Radio 4 on June 16 and 23, 2006.
- A radio parody inspired by the film adaptation was made as part of the Crème de la Crime series by Punt and Dennis, also on BBC Radio 4.
- A Spanish video game adaptation was released in 1987 under the title La Abadía del Crimen (The Abbey of Crime).
- Ravensburger published an eponymous boardgame in 2008, written by Stephan Feld and is based on the events of the book.
- An adventure video game adaptation titled, Murder in the Abbey (2008), was developed by Alcachofa Soft and published by DreamCatcher Interactive.
- The British Melodic Hard Rock band Ten released the album The Name of the Rose (1996), whose eponymous track is loosely based around some of the philosophical concepts of the novel.
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