In the 1979 film Apocalypse Now, Dennis Hopper's character, the photojournalist, in comparing himself to Colonel Kurtz says "I should have been a pair of ragged claws, scuttling across [the] floor of silent seas."
A 1982 track from Los Angeles punk band Rhino 39, "J.Alfred" contains several obvious paraphrases and references to the poem.
The 1994 single "Pretty Good Year" by musician Tori Amos references Prufrock with the lyric, "Heard the eternal footman bought himself a bike to race".
The popular Texan author Kinky Friedman named his 1996 novel The Love Song of J. Edgar Hoover in reference to Eliot's work.
The English folk/punk musician Frank Turner released a song title "I Knew Prufrock Before He Was Famous" in 2008 on his second studio album "Love Ire & Song".
In the pilot episode of the television series Nurse Jackie aired in 2009, the title character quotes the first three lines of the poem.
In Bo Burnham's song "Repeat Stuff", he recites the first three lines of the poem, commenting, "T.S. Eliot. Beautiful."
In the 2014 film It Follows, a college professor reads the poem to a classroom of students. The reading coincides with the main character, Jay, watching an elderly woman stalk her through the classroom window.
In the 2014 film "I wish I was here" the main character Aidan Bloom reads a part of this poem to his children.
The titles of the 2015 tracks "Human Voices" and "And We Drown" by Australian musician Patch Hutley, under the pseudonym of ᴅᴀɪᴋᴜ ɪɴᴅᴜsᴛʀɪᴇs, both reference the final stanza of the poem.