Rodion Schedrin composed a ballet in one act The Lady with the Lapdog, first performed on 20 November 1985 in Moscow by the Bolshoi Theatre, Alexander Lazarev (cond).
A 1960 film version was produced by Josef Heifitz and starred Alexei Batalov and Iya Savvina. It won a Special Prize for "lofty humanism and artistic excellence" at the 1960 Cannes Film Festival.
An adaptation of The Lady with the Dog, Dark Eyes (Italian: Oci ciornie; Russian: Очи чёрные; French: Les Yeux noirs) is a 1987 Italian and Russian language film which tells the story of a 19th-century married Italian who falls in love with a married Russian woman. It stars Marcello Mastroianni, Silvana Mangano, Oleg Tabakov, Yelena Safonova, Pina Cei and Vsevolod Larionov. The film was adapted by Aleksandr Adabashyan, Suso Cecchi d'Amico and Nikita Mikhalkov, "inspired by" stories by Anton Chekhov. It was directed by Mikhalkov. Mastroianni received Best Actor at the Cannes Film Festival and was nominated for the Academy Award for Best Actor.
The story has also been adapted for stage; for example, an adaptation by Peter Campbell was featured at the 2002 Chekhov Now Festival in New York. A play titled Sunstroke, directed by Oleg Mirochnikov, combines The Lady with the Dog with Ivan Bunin's Sunstroke. The play was performed in 2013 at the Platform Theatre in London. An opera version titled "The Lady with the Pet Dog" was premiered at Cornell College in Mount Vernon, Iowa in 2010.
Joyce Carol Oates wrote a short story adaptation of the story also entitled "The Lady with the Pet Dog" published in 1972. Oates' story is told from Anna's point of view and is set in New York and Nantucket.
Brian Friel's play The Yalta Game (2001) is loosely based on this short story by Chekhov.