The Killer Angels was the source for the screenplay for the 1993 movie Gettysburg. Much dialogue in the movie comes directly from the book.
The Firefly science fiction television series was developed by Joss Whedon after reading The Killer Angels. Homage to Shaara's novel was paid in the series' final episode, "Objects in Space".
Singer-songwriter Steve Earle included a song on his 1999 bluegrass album, The Mountain, called Dixieland, sung from the point of view of the character Buster Kilrain.
A stage adaptation by Karen Tarjan was originally produced at Lifeline Theatre in Chicago in 2004, and again in the Fall of 2013. The adaptation was subsequently produced at Anchorage Community Theatre, the Wayside Theatre in Virginia, the Heritage Theatre in Maryland and Mother Road Theatre in New Mexico.