- The 1941 movie The Life and Death of Colonel Blimp makes references to The Hound of the Baskervilles.
- In 1960 the Disney cartoonist Carl Barks made a parody of this story, The Hound of the Whiskervilles, starring Uncle Scrooge. A 1965 issue of Walt Disney's Comics and Stories (comic book) featured The Hound of Basketville, starring Mickey Mouse, Goofy, Gladstone Gander, and Pluto, as Sherlock Mouse, Doctor Goofy, Sir Gladstone Basketville, and the hound.
- Pierre Bayard's 2008 book Sherlock Holmes Was Wrong re-opens the case and, by careful re-examination of all the clues, clears the hound of all wrongdoing and argues that the actual murderer got away with the crime completely unsuspected by Holmes, countless readers of the book over the past century—and even, in a sense, the author himself.
- The Moor, a 1998 novel in Laurie R. King's series about Sherlock Holmes and Mary Russell, uses the setting and various plot elements, with Holmes returning to Dartmoor on a later case.
- In 1997, Spike Milligan satirised the novel in his book, The Hound of the Baskervilles According to Spike Milligan, combining elements of the original novel with the Basil Rathbone serials.
- The hound of Baskerville also is a character in the anime\manga Hellsing
- In Richard L. Boyer's version of The Giant Rat of Sumatra, Stapleton reappears. After capturing Watson by a trick, he tells him everything that happened. It turns out that he did not die as Holmes and Watson believed at the time (and as Watson gave his readers to believe when he wrote the about the hound) but had escaped by another route, and had become a gypsy. He meets a man named Jones, who helps him in his crimes. The giant rat is a tapir that Stapleton had got from some natives. Holmes, however, had already deduced everything, and was prepared for him. Stapleton finally is punished after five years of getting away with his crime.
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