The Hot Zone

Which system is attacked first? Why is this important?

Chapter 5: project ebola

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Ebola proteins attack the immune system first. This is important because it leaves the body unable to defend itself against the virus.

Whatever these Ebola proteins do, they seem to target the immune system for special attack. In this they are like HIV, which also destroys the immune system, but unlike the creeping onset of HIV, the attack by Ebola is explosive. As Ebola sweeps through you, your immune system fails, and you seem to lose your ability to respond to viral attack.
Source(s)

Preston, Richard. The Hot Zone: The Terrifying True Story of the Origins of the Ebola Virus (p. 64). Knopf Doubleday Publishing Group. Kindle Edition.