In 1950, along with novelist John Oliver Killens, Rosa Guy formed a workshop that was to become the Harlem Writers Guild (HWG). Its goal was "to develop and aid in the publication of works by writers of the African Diaspora". Its members and participants included Willard Moore, Walter Christmas, Maya Angelou, Dr. John Henrik Clarke, Paule Marshall, Audre Lorde, Alice Childress, Ossie Davis, Ruby Dee, and Douglas Turner Ward. It was very influential, nurturing more than half of all successful African-American writers between 1950 and 1971; they were associated with the workshop. Guy also belonged to the Black nationalist literary organization On Guard for Freedom, founded by Calvin Hicks on the Lower East Side of New York City. Among On Guard's other members were LeRoi Jones, Sarah E. Wright and Harold Cruse.
Rosa Guy died in 2012. Her obituary was included in The Socialite who Killed a Nazi with Her Bare Hands: And 144 Other Fascinating People who Died this Year, a collection of New York Times obituaries published in 2012.