Any changes that can have from the outer changes in Usher.
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Certainly the House of Usher is deteriorating,
"The discoloration of ages had been great. Minute fungi overspread the whole exterior, hanging in a fine tangled web-work from the eaves. Yet all this was apart from any extraordinary dilapidation."
We can infer that the house has been unkept for a very long time meaning the people inside have been too sick (mental or physical) to allow their property to sink so low.