In 1955, the book was made into a film, directed by Edward Dmytryk, with the screenplay adaptation by Lenore J. Coffee. David Lewis was the producer and David E. Rose executive producer. It starred Deborah Kerr as Sarah Miles, Van Johnson as Maurice Bendrix, John Mills as Albert Parkis, and Peter Cushing as Henry Miles.
In 1999, the novel was again made into a film (The End of the Affair), directed by Neil Jordan. Jordan also wrote the screenplay and produced the film with Stephen Woolley. It starred American actress Julianne Moore as Sarah Miles, English actor Ralph Fiennes as Maurice Bendrix, and Irish actor Stephen Rea as Henry Miles. Julianne Moore was nominated for an Academy Award for Best Actress for her performance.
In 2004, Jake Heggie composed an opera based on the novel. It premiered at the Houston Grand Opera in March of that year, and was subsequently revised into its final form.
In 2011, the novel was adapted into a play by Karla Boos and had its world premiere at Quantum Theatre.
In 2012, an audio edition performed by Colin Firth and produced by Audible.com was released; the recording was recognized as Audiobook of the Year at the Audies Gala in May 2013.
Various websites have opined that the 2012 Bollywood film Jab Tak Hai Jaan might have drawn inspiration from the novel.
The Italian band Daisy Chains has released an album titled A Story Has No Beginning or End, which is the first line of the novel by G. Greene, and whose own second track is titled "The End of the Affair".