A stage adaptation, by Simon Stephens and directed by Marianne Elliott, premiered at the National Theatre on 2 August 2012. It starred Luke Treadaway as Christopher, Nicola Walker as his mother Judy, Paul Ritter as his father Ed, Una Stubbs as Mrs Alexander and Niamh Cusack as Siobhan. The production, which ran until late October 2012, was broadcast live to cinemas worldwide on Thursday 6 September 2012 through the National Theatre Live programme.
The show transferred to the Apollo Theatre in Shaftesbury Avenue, London, from March 2013. On 19 December 2013, during a performance of The Curious Incident at the Apollo, parts of the ceiling fell down injuring around 80 of the over 700 patrons inside. The production re-opened at the Gielgud Theatre on 24th June 2013.  New cast production photographs at the Gielguid Theatre London. The new West End cast is led by Sion Daniel Young as Christopher Boone. He is joined by Rebecca Lacey as Siobhan, Nicolas Tennant as Ed, Mary Stockley as Judy, Jacqueline Clarke as Mrs Alexander, Indra Ové as Mrs Shears, Stephen Beckett as Roger Shears, Matthew Trevannion as Mr Thompson, Pearl Mackie as No. 40/Punk Girl, Sean McKenzie as Reverend Peters and Kaffe Keating plays alternate Christopher. They are joined by Mark Rawlings, Penelope McGhie, Naomi Said and Simon Victor.  An adaptation and translation into Spanish by María Renée Prudencio played at the Teatro de los Insurgentes in Mexico City in June 2014. The character of Christopher was played by Luis Gerardo Méndez and by Alfonso Dosal on alternate days.
A film adaptation, written and directed by Steve Kloves, is currently being planned. The film rights were optioned by Brad Grey and Brad Pitt for Warner Brothers.