In 1993–4, David Fishelson's stage adaptation was produced Off-Broadway in New York City at Jean Cocteau Repertory at the Bouwerie Lane Theatre. After a favorable review in The New York Times, the play was published by Dramatists Play Service, dramatized by L.A. Theatre Works, and later broadcast on NPR on the NPR Playhouse series.
A stage adaptation by Anthony Clarvoe had its world premiere at Cincinnati Playhouse in the Park and the Repertory Theater of St. Louis in 1995. It is published by Broadway Play Publishing Inc.
In June 2011, Myriad Productions staged their original adaptation of The Brothers Karamazov at Barons Court Theatre, London, and again in 2014 at King's Head Theatre in Islington
On October 17, 2013, Theater-by-the-Grove at Indiana University of Pennsylvania staged an adaptation of The Brothers Karamazov.