A staged version of the novel, called Fukú Americanus, was adapted by Sean San Jose and co-directed by San Jose and Marc Bamuthi Joseph through San Jose’s Campo Santo theatre company in 2009. The production received mixed reviews, with one critic stating that "“Fukú" doesn't show us how that works or what the curse has to do with anything... for that, you have to read the book."
The novel's film rights were optioned by Miramax Films and producer Scott Rudin in 2007. Director Walter Salles and writer Jose Rivera (The Motorcycle Diaries) were hired by Rudin to adapt the novel. According to Diaz, Miramax's rights on the book have since expired.