- The Big Sleep, a 1946 film starring Humphrey Bogart
- The Big Sleep, a 1978 film starring Robert Mitchum
- It was adapted for radio by Bill Morrison, directed by John Tydeman, and broadcast on BBC Radio 4 on 26 September 1977, starring Ed Bishop as Marlowe.
- It was again adapted by BBC Radio 4 and broadcast on 5 February 2011, directed by Claire Grove and starring Toby Stephens as Marlowe.
- Perchance to Dream, Robert B. Parker's authorized 1990 sequel
- The Coen brothers' film The Big Lebowski is inspired by the character Philip Marlowe and the style and plot elements of Chandler's novels such as The Big Sleep.
- The Big Sleep, a stage adaptation by Alvin Rakoff and John D. Rakoff, premièred in October 2011 at The Mill at Sonning, Berkshire, UK.
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