- The Big Sleep, a 1946 film starring Humphrey Bogart and directed by Howard Hawks
- Television adaptation by Richard Morrison, directed by Norman Felton and starring Zachary Scott, broadcast on 25 September 1950
- The Big Sleep, a 1978 film starring Robert Mitchum and directed by Michael Winner
- Adaptation for radio by Bill Morrison, directed by John Tydeman, and broadcast on BBC Radio 4 on 26 September 1977, starring Ed Bishop as Marlowe
- Another adaptation by BBC Radio 4, directed by Claire Grove and broadcast on 5 February 2011, starring Toby Stephens as Marlowe
- Perchance to Dream, Robert B. Parker's authorised 1990 sequel
- The Coen brothers' film The Big Lebowski was inspired by the character Philip Marlowe and the style and plot elements of Chandler's novels such as The Big Sleep.[7][8]
- The Big Sleep, a stage adaptation by Alvin Rakoff and John D. Rakoff, premièred in October 2011 at The Mill at Sonning, Berkshire, UK. Dan Chameroy played Marlowe.
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