- Jack Lemmon as Calvin Clifford (CC) "Bud" Baxter
- Shirley MacLaine as Fran Kubelik
- Fred MacMurray as Jeff D Sheldrake, personnel manager, Baxter's boss and apartment user
- Ray Walston as Joe Dobisch, office manager and Baxter apartment user
- Jack Kruschen as Dr David Dreyfuss, Baxter's neighbor
- Frances Weintraub Lax as landlady Mrs Lieberman, always accompanied by her little dog Oscar
- David Lewis as Al Kirkeby, manager and Baxter apartment user
- Edie Adams as Miss Olsen
- Hope Holiday as Mrs Margie MacDougall
- Joan Shawlee as Sylvia
- Naomi Stevens as Mrs Mildred Dreyfuss
- Johnny Seven as Karl Matuschka (Fran's cab driving brother-in-law)
- Joyce Jameson as the blonde in the bar
- Hal Smith as Santa Claus in the bar
- Willard Waterman as Mr Vanderhoff, manager and Baxter apartment user
- David White as Mr Eichelberger, manager and Baxter apartment user
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