Lehninger Principles of Biochemistry 6th Edition

Published by W.H. Freeman
ISBN 10: 1-42923-414-8
ISBN 13: 978-1-42923-414-6

Chapter 4 - The Three-Dimensional Structure of Proteins - Problems - Page 153: 5

Answer

$(a)$Disufide bond is the molecular basis for the correlation between disulfide-bond content and mechanical properties of the protein. $(b)$Cystine residues (disulfide bonds) is the molecular basis for this property.

Work Step by Step

$(a)$Disufide bonds are covalent bonds, which are much more stronger than the noncovalent interactions that stabilize most proteins. They cross-link chains, increase their stiffness, mechanical strength, and hardness. $(b)$Cystine residues (disulfide bonds) prevent the complete unfolding of proteins.
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