Lehninger Principles of Biochemistry 6th Edition

Published by W.H. Freeman
ISBN 10: 1-42923-414-8
ISBN 13: 978-1-42923-414-6

Chapter 25 - DNA Metabolism - Problems - Page 1054: 8

Answer

A variety of factors are responsible for maintianing the fidelity of replication, including DNA polymerase function, mismatch repair processes, and the chemical condition of the DNA template. Since the lagging strand is synthesized in fragments, it will demonstrate a higher level of fidelity. A similar hypothesis has been supported by lacZ studies in E. coli.

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