Lehninger Principles of Biochemistry 6th Edition

Published by W.H. Freeman
ISBN 10: 1-42923-414-8
ISBN 13: 978-1-42923-414-6

Chapter 14 - Glycolysis, Gluconeogenesis, and the Pentose Phosphate Pathway - Problems - Page 583: 8

Answer

The transformation of glucose to lactate occurs when Myocytes are low in oxygen, and it provides a means of generating ATP under $O_{2}$-deficient conditions. Because lactate can be oxidized to pyruvate, glucose is not wasted; pyruvate is oxidized by aerobic reaction when $O_{2}$ becomes plentiful. This metabolic flexibility gives the organism a greater capacity to adapt to its environment.

Work Step by Step

No, anaerobic glycolysis in muscle is not a wasteful use of glucose.
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