Lehninger Principles of Biochemistry 6th Edition

Published by W.H. Freeman
ISBN 10: 1-42923-414-8
ISBN 13: 978-1-42923-414-6

Chapter 12 - Biosignaling - Problems - Page 498: 12

Answer

Shared properties of Ras and $G_{s}$; Both bind either GDP or GTP; both are activated by GTP; both, when active, activate a downstream enzyme; both have intrinsic GTPase activity that shuts them off after a short period of activation. Difference between Ras and $G_{s}$; $Ras$ is a small, monomeric protein; $G_{s}$ is Hetrotrimeric. Functional difference between $G_{s}$ and $G_{i}$; $G_{s}$ activates adenylyl cyclase, $G_{i}$ inhibits it.

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