Lehninger Principles of Biochemistry 6th Edition

Published by W.H. Freeman
ISBN 10: 1-42923-414-8
ISBN 13: 978-1-42923-414-6

Chapter 12 - Biosignaling - Problems - Page 497: 1

Answer

Albuterol raises cAMP, leading to relaxation and dilation of the bronchi and bronchioles. Beacause $Beta$-adrenergic receptors control many other processes, this drug would have undesirable side effects. To minimize them, find an agonist specific for the subtype of $beta$-adrenergic receptors found in the bronchial smooth muscle.

Work Step by Step

Yes, we expect this drug to have side effects. Might one design a better drug by finding an agonist specific for the subtype of $beta$-adrenergic receptors found in the bronchial smooth muscle?
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