Biology (11th Edition)

Published by McGraw-Hill Education
ISBN 10: 1-25918-813-2
ISBN 13: 978-1-25918-813-8

Chapter 13 - Chromosomes, Mapping, and the Meiosis-Inheritance Connection - Review Questions - Synthesize: 3

Answer

Since Calico coloration results from X-inactivation, which requires two X chromosomes, but these are males which normally have one X chromosome. Thus, the 1/3000 must be XXY males (Klinefelter's syndrome), since these can have X-inactivation.

Work Step by Step

To get to this answer, the key is that Calico coloration requires X-inactivation, which, in turn, requires two X-chromsomes. Then, it is simply a matter of finding a way that a male can have two X chromosomes.
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