Answer
Self-tolerance: Each antibody produced by B cells must be relatively unresponsive to self antigens so that it does not attack the body's own cells
In the bone marrow b cells that show an inclination to attack self proteins are sent information to die --apoptosis, or are inactivated --anergy.
In the thymus T cells are not encouraged to develop clones --negative thymic selection, or they are killed off by the thymus--clonal deletion.
Immunocompetence :
Each B lymphocyte mus become able to recognize its specific antigen by binding to it. This ability is immunocompetence.
Work Step by Step
When B-cells become immunocompetent they display unique receptors on their surfaces. These many receptors enable the immune cells to recognize and bind specific antigens.. Once these receptors appear on the lymphocyte surface, it is committed to react to only one distinct antigenic determinant, because all of its antigen receptors will be identical . The receptors on B-cells are membrane-bound antibodies; the receptors on T-cells are products of the same family of genes, and perform the same function.
