Answer
The increase of permeability of capillary walls due to inflammation, results in increased amount s of inflammatory exudate flowing into interstitial spaces(ISS). This represents not only an increased volume of ISF/exudate, but changes in amounts and chemical composition. Some of these chemicals (kinins, interleukins, interferons) may temporarily be pro-inflammation, but most of them, for example, the proteins, have unequivocal beneficial effects;
Some important chemicals that increase in inflammatory exudates are antibodies, clotting factors, complement, and fibrinogen. Antibodies cooperate in complement fixation and lysis of pathogens; they also promote phagocytosis by opsonization. Clotting factors-- Hageman, prothrombin, fibrin-- help to form a gel-like mesh that limits the spread of the infectious agent or toxin. Fibrinogen facilitates the formation of the meshwork which also limits spread of inflammation and facilitates repair of damaged tissues. Complements attract phagocytes and stimulate the killing of microbes.
Work Step by Step
Other substances in inflammatory exudates that are beneficial include amino acids to nourish cells and other nutrients --in increased amounts to nourish cells under pressure--, as well as leukocyte attracting cytokines of various types.
