Anatomy & Physiology: The Unity of Form and Function, 7th Edition

Published by McGraw-Hill Education
ISBN 10: 0073403717
ISBN 13: 978-0-07340-371-7

Chapter 18 - Section 18.5 - Platelets and Hemostasis-The Control of Bleeding - Apply What You Know - Page 702: 1

Answer

Hemophilia is a genetic disorder characterized by a deficiency of clotting factors in the blood, which leads to impaired blood clotting and a tendency to bleed excessively. Aspirin, a common over-the-counter medication, has the ability to inhibit the function of platelets, which are essential components in the blood clotting process. While aspirin doesn't actually "thin" the blood, it does interfere with platelet function by inhibiting the production of thromboxane, a molecule that promotes platelet aggregation and blood clot formation. By reducing the ability of platelets to clump together and form clots, aspirin increases the risk of bleeding. For people with hemophilia, who already have a reduced ability to form blood clots due to their clotting factor deficiency, the use of aspirin can further exacerbate this problem and lead to increased bleeding. Even minor injuries or internal bleeding could become more severe if the blood is unable to clot properly. Therefore, individuals with hemophilia are generally advised to avoid using aspirin or any other medications that can interfere with blood clotting, unless specifically directed by their healthcare provider. It's important for them to work closely with their medical team to manage their condition and make informed decisions about medications to ensure their safety and well-being.

Work Step by Step

Hemophilia is a genetic disorder characterized by a deficiency of clotting factors in the blood, which leads to impaired blood clotting and a tendency to bleed excessively. Aspirin, a common over-the-counter medication, has the ability to inhibit the function of platelets, which are essential components in the blood clotting process. While aspirin doesn't actually "thin" the blood, it does interfere with platelet function by inhibiting the production of thromboxane, a molecule that promotes platelet aggregation and blood clot formation. By reducing the ability of platelets to clump together and form clots, aspirin increases the risk of bleeding. For people with hemophilia, who already have a reduced ability to form blood clots due to their clotting factor deficiency, the use of aspirin can further exacerbate this problem and lead to increased bleeding. Even minor injuries or internal bleeding could become more severe if the blood is unable to clot properly. Therefore, individuals with hemophilia are generally advised to avoid using aspirin or any other medications that can interfere with blood clotting, unless specifically directed by their healthcare provider. It's important for them to work closely with their medical team to manage their condition and make informed decisions about medications to ensure their safety and well-being.
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