Answer
$(t^2+4y^2)(t^4-4t^2y^2+16y^4)$
Work Step by Step
Using $a^3+b^3=(a+b)(a^2-ab+b^2)$ or the factoring of 2 cubes, the factored form of the given expression, $
t^6+64y^6
,$ is
\begin{array}{l}
(t^2+4y^2)[ (t^2)^2-(t^2)(4y^2)+(4y^2)^2]
\\\\=
(t^2+4y^2)(t^4-4t^2y^2+16y^4)
.\end{array}