Answer
$16x^4-81$
Work Step by Step
Use the formula $(a+b)(a-b)$ to multiply the last 2 factors to obtain:
$=(4x^2+9)[(2x)^2-3^2]
\\=(4x^2+9)(4x^2-9)$
Use the same formula again with $a=4x^2$ and $b=9$ to obtain:
$=(4x^2)^2-9^2
\\=16x^4-81$