Answer
$3y^2*(x+3)(x^2-3x+9)$
Work Step by Step
$3x^6y^2+81y^2$
$y^2*(3x^6+81)$
$3y^2*(x^6+27)$
$x^6+27=x^3+3^3$
$a^3+b^3=(a+b)(a^2-ab+b^2)$
$x^6+27= (x+3)(x^2-3x+3^2)$
$x^6+27= (x+3)(x^2-3x+9)$
$3y^2*(x^6+27)$
$3y^2*(x+3)(x^2-3x+9)$